The political factor such as the common hostility with the Ottomans and an economic factor such as the exchange of goods and manufactured products, including Europe's need for Iranian silk, have been effective in establishing Iran's relations with Europe. In addition to these two, the religious factor has also been effective on the part of the Europeans in spreading Christianity in the East and allowing the establishment of Christian religious sects in Iran to develop bilateral relations. What played an important role in the field of transferring goals and objectives and exchanging negotiations and interactions was the human factor, namely translators of various languages ​​into Persian and vice versa, who facilitated these relations and made the concepts understandable and comprehensible for both parties. In this article, the role of translators in Iran's political and trade relations with European countries during the Safavid era has been examined using a library method and a descriptive-analytical approach. The research findings show that translators were an intermediary between Iran and Europe and made negotiations and communication understandable and comprehensible for both parties.